Investigations have highlighted many roles in which it is used including antioxidant defense, detoxification of electrophilic xenobiotics, modulation of redox regulated signal transduction, storage and transport of cysteine, regulation of cell proliferation, synthesis of deoxyribonucleotide synthesis, regulation of immune responses, and regulation of leukotriene and prostaglandin metabolism[13]
Most common side effects are GI (nausea, vomiting, diarrhea)manageable with slow titration
3 studies referred to GSH but did not give data, 5 studies were conference abstracts we were unable to gain access to this data, despite three attempts at email correspondence with the authors
In this section, we summarize the research progress on various natural products that regulate gut microbiota composition and structure, reduce TMAO levels, and ultimately improve disease outcomes (Table 8)