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Interestingly, there is evidence for reduced striatal DA levels in both R6/2 and YAC128 mice at later disease stages concomitant with motor abnormalities 50,51,52

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A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX

However, effectiveness also depends on: Tolerability Dose escalation Patient adherence Lifestyle support Difference between Mounjaro and Wegovy: Dosing and Titration Both treatments are usually started at a lower dose and increased gradually