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And even the US Food and Drug Administration , hardly a champion of tobacco harm reduction, has authorized one HTP brand to be marketed as modified risk recognizing that it presents reduced exposure to harmful elements and is expected to benefit the health of the population. In real-world scenarios, heated tobacco products are demonstrated to be direct competitors to combustible cigarettesand have reduced cigarette sales at astonishing rates in markets where they are legally sold

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To further refine the structure activity relationship of CYP2A6, previously synthesized 3-alkynyl and 3-heteroaromatic substituted pyridine methanamines were used as lead compounds