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Also known as vitamin BT, it exists naturally in our cells and its supplementation in the form of l-carnitine has become popular in recent years

The selective ULK1/2 inhibitor, DCC-3116, synergizes with the KRASG12C inhibitor sotorasib to suppress KRAS-driven LC, whereas this combination has been assessed only in early preclinical stages and lacks predictive biomarkers for patient stratification (17)

The R-isomer is the biologically active form responsible for the antioxidant and metabolic effects observed in clinical studies

In this context, it has been demonstrated that the restoration of -cell mass can occur not only through proliferation of existing -cells but also via transdifferentiation of other pancreatic cell types, such as -, -, PP-, and ductal epithelial cells (Figure 1B)