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Beyond these systemic benefits, evidence now suggests that GLP-1 receptor activation has direct effects on hepatocytes, contributing to reductions in steatosis, inflammation, and fibrosis

Patients should maintain adequate hydration (68 drinks daily), consume electrolyte-rich foods, and seek medical attention for persistent vomiting/diarrhoea, palpitations, severe muscle weakness, or confusion

Additionally, the superiority of GLP-1RAs compared to placebo in the primary endpoint of 3-MACE were found with liraglutide in the LEADER trial (HR 0.87

Furthermore, a mean 4.9-year (maximum 10-year) follow-up study revealed that patients who tested positive for GIP-Abs had a significantly worse prognosis than those who tested negative for GIP-Abs