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Overall, DPP4i, as a class of safe oral hypoglycemic agents, have a role in the management of diabetic patients, and there is extensive experience in their use
A recent meta-analysis including data from SURMOUNT-1, a trial conducted in individuals with obesity, confirmed the favorable effects of tirzepatide on dyslipidemia, finding a 16 and 13.7% change from baseline in triglycerides and very low-density lipoproteins with tirzepatide 15 mg vs
Further studies are needed to elucidate the precise mechanisms and potential therapeutic implications of targeting UA in the context of misfolded protein-related neurodegenerative diseases
Biessels & Gispen, 2005)
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