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doi: 10.1007/978-3-642-60946-6_30 17 RolfeDFBrownGC

The resulting reactive oxygen species (ROS) activate the Apoptosis Signal-regulating Kinase 1 (ASK1)-c-Jun N-terminal Kinase (JNK)/p38 pathway, inducing DNA damage and mitochondrial membrane permeability transition (MPT) 49