tirzepatide vs semaglutide study NEJM recently published a pivotal comparing “Tirzepatide” and “ Semaglutide” for the Treatment of Obesity tirzepatide vs semaglutide weight loss

Blood Glucose and HbA1c Changes Observed in the Trial The 12 mg dose produced mean HbA1c reductions of approximately 2.2 percentage points (~24 mmol/mol) at 24 weeks, with some participants reaching HbA1c levels below the 48 mmol/mol diagnostic threshold for type 2 diabetes

Schunkert reported personal fees from AstraZeneca, Bayer Vital GmbH, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, MSD, Novartis, Pharmacosmos, Sanofi, Servier, Synlab, Amgen, and Amarin outside the submitted work

In patients with obesity-related hormonal imbalancesparticularly those with polycystic ovary syndrome (PCOS) or metabolic syndromesignificant weight loss can lead to improvements in acne severity through normalization of insulin and androgen levels

*In clinical studies, patients using benzoyl peroxide experienced noticeable improvement in acne severity within 48 weeks compared to placebo