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Clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease: a systematic review

They work by mimicking the GLP-1 hormone, which is produced in the small intestine, in effect, tricking the body into slowing digestion, releasing more insulin and reducing appetite, hunger and ultimately the amount of food consumed

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No fiber supplement has been specifically studied in combination with tirzepatide in clinical trials, but general principles of fiber supplementation and GLP-1 receptor agonist therapy inform these recommendations