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Glutathione is a water-soluble active that does not readily penetrate the skin on its own, which is why advanced formulation strategies are essential to enhance its delivery and bioavailability

Consistent with a link between low selenium and the effects of the GPx1 polymorphisms, in regions endemic for Keshan disease, there was a significant difference in the distribution of alleles in cases and controls, with a greater risk for individuals with the Pro/Leu or Leu/Leu genotypes of developing Keshan disease [36]

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