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Cell 88 , 131141 (1997)

More recently, a multiple hits theory has been proposed, with the addition of other pathogenic factors in NAFLD development: low-grade chronic inflammation, genetic and epigenetic mutations, and intestinal microbiota

Along with classical (Clarks and McGoverns) subtypes of melanoma, other melanocytic malignancies, each charcaterized by peculiar biological behavior probably exist, must be distinguished from classical melanoma subypes and require specific clinical guidelines

It addresses glucose at two different points in the metabolic cycle reducing the amount absorbed from the intestine while simultaneously improving how efficiently cells take it up.*