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Additionally, in pSS-related experimental animal studies, SCFAs modulate aberrant activation of B cells and dendritic cells by activating the aryl hydrocarbon receptor (AhR) or by suppressing NF-B signaling, thereby alleviating lymphocyte infiltration in exocrine glands (209)

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Rescue therapy was needed by 8%, 25%, and 67%, respectively. Five milligrams preserved most, but not all, of the benefit of continuing the effective dose