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Why GLP-1 Agonists May Increase Kidney Stone Risk The primary mechanism linking GLP-1 agonists to kidney stones is dehydration
The results were compelling: patients on Zepbound lost 15%, 19.5%, and 20.9% of their body weight at the respective doses, compared to just a 3.1% weight loss in those who received the placebo
Further reading: Retatrutide side effects Note: Retatrutide is currently still undergoing clinical trials and has not been approved for use in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA)
While Ozempic is FDA-approved for type 2 diabetes and offers added weight loss benefits, compounded semaglutide lacks FDA approval and is no longer widely available following the resolution of a semaglutide shortage in March 2025
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