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Similar to ghrelin, GLP-1 exerts central effects via complementary mechanisms acting on GLP-1R (Kanoski et al., 2016)

doi: 10.1080/10408398.2020.1784841

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Tirzepatide is a dual-agonist found in Zepbound and Mounjaro, which targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors