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67,68 Specifically, female sex hormones including estradiol (e.g., 17-oestradiol) 69 protect female proopiomelanocortin (POMC) neurons from IR by enhancing POMC neuronal excitability and coupling insulin receptors to transient receptor potential (TRPC) channel activation
In the SURMOUNT series, patients on tirzepatide achieved up to 22% body weight reduction over 68 weeks, compared to 17% with semaglutide in similar studies
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