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As discussed earlier, OS is critically involved in the pathogenesis of IRI

[,,] The most important antioxidant in the body to fight the oxidative stress is reduced GSH, which is considered a health parameter to evaluate the patients status in many diseases

The consequence of inhibiting AMP resistance was observed in a sapA mutant which had an attenuated ability to survive in both the nasopharynx and the chinchilla middle ear, compared to the parent strain (Mason et al., 2005