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Subdoligranulum genus was significantly more abundant in patients with poor gut integrity and high gut permeability ( Lachnospiraceae exhibited higher relative abundance in patients with inflammatory bowel disease (IBD) and further led to severe colitis (Quraishi et al., 2017), and the Lachnospiraceae_NK4A136_group is the main genus of Lachnospiraceae

Predictors and outcomes of ustekinumab dose intensification in ulcerative colitis: a multicenter cohort study