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Smoking and Alcohol Consumption: Both smoking and excessive alcohol intake are known to degrade collagen and impair the body's natural healing processes, potentially leading to weaker GHK-Cu results

Given this background and the fact that the apparent potency of ALT-801 for the GLP-1R is comparable to that of semaglutide (EC 50 of 39 pM and 15 pM, respectively 20 ) it is reasonable to conclude that GCGR activation is responsible for the improved activity of ALT-801 over semaglutide in this NASH model

5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide tablets [see Adverse Reactions (6)]

Many people experience gastrointestinal issues, such as nausea, diarrhea, vomiting and constipation