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The mechanism of action of GLP-1RA to promote weight loss mainly includes the reduction of fat deposition through regulation of adipose tissue (lipolysis, fatty acid oxidation, and adipocyte differentiation) and the reduction of food intake through the central and peripheral nervous system

Animal cognition studies: Rats treated with Dihexa show dramatically improved performance on spatial memory tasks, with some studies suggesting effects comparable to reversing years of age-related cognitive decline

Aging Res

Noncoding RNAs can also regulate endothelial ferroptosis: microRNA-17-92 enhances resistance to Erastin-induced ferroptosis in endothelial cells in vitro [91], while circRNA-itchy E3 ubiquitin protein ligase (circ-ITCH) activates the Nrf2 pathway by recruiting TATA-box-binding protein associated factor 15 (TAF15), inhibiting ferroptosis and improving angiogenic capacity in HUVECs [92]