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This constant immune surveillance can eventually misfire, targeting the bodys own tissues

Research has demonstrated that these reactions are highly sensitive to NAD+ availability, with studies showing that 20-30% reductions in mitochondrial NAD+ levels can decrease citric acid cycle flux by 40-60%

2021 Feb Hamid Reza Mohammadi, Ebrahim Khoshnam, Maryam Koshki Jahromi, Mohammad Sadegh Khoshnam, Elham Karampour

Funding This work was supported by the Key Research and Development Program of Xinjiang Uygur Autonomous Region of China [2022B03019-1-1] and Youth Project of the Institute of Medical Sciences, Xinjiang Medical University [YXYJ20230301]