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Slower gastric motility causes retention of food and secretions in the stomach, increasing visceral sensory signaling that feels like fullness or queasiness, while central receptor activation can alter nausea thresholds

Furthermore, the agonists act on the hypothalamus and other brain regions involved in appetite regulation, reducing hunger and food intake (Collins & Costello., 2024

GHK-Cu does not drive accelerated cell turnover, which is the underlying mechanism of retinol purging