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The utility of putative blood biomarkers, including glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), S100 calcium-binding protein B (S100B) and Neurofilament-light (NF-L), has been evaluated by multicenter studies such as ALERT, CENTER-TBI, TRACK-TBI and BIO-AX-TBI [5, 21]

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