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In particular, both superoxide dismutase (SOD) and catalase (CAT) play crucial antioxidant roles in the epidermis, showing a gradient of activity that decreases toward the skin surface

This combination treatment significantly improved behavior, reduced mast cell infiltration and decreased oxidative and nitrosative stress and inflammation compared to reserpine-treated rats

Unpaired Students t -test (or MannWhitney U test), paired Students t -test (or Wilcoxon signed-rank test), and one-way ANOVA or two-way ANOVA test followed by Bonferronis test for multiple comparisons were used to determine statistical differences

& Arendt, J