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J Pediatr 175:206210

Improves Glycemic Control: In persons with type 2 diabetes, retatrutide lowers HbA1c and fasting glucose levels, with efficacy sometimes exceeding established glucose-lowering medications 1,2

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The company said in a later investor presentation that its decision to start the phase three trials was based on data including real-world evidence studies showing lower risks of dementia among people on GLP-1 medicines, analyses of effects seen in other clinical trials and animal studies showing that the drugs are associated with improved memory function, reduced neuroinflammation and systemic anti-inflammatory effects