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1997 A model for p53-induced apoptosis Nature 389 : 300305 Kroemer G, Zamzami N, Susin SA

Thats where some of the affordability concerns are coming from: large populations are potentially eligible to take these drugs, and we cant pay for a lifetime supply for everyone. The researchers model suggested that even though the alternative weight-maintenance programs might be slightly less effective than long-term, full-dosage GLP-1RA use, the clinical benefits would only decrease slightly, while lifetime healthcare spending would decrease substantially

Genomewide association study of acute anterior uveitis identifies new susceptibility loci