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Self-initiated combination therapy without medical supervision is not advisable given the complexity of managing potential adverse effects and the need for appropriate clinical monitoring

71 This safety margin in animals is reassuring, though it doesnt guarantee the same in humans

For individuals with binge eating disorder, the psychological impact of gastrointestinal side effects warrants particular attention

Jerold Mande, CEO of the nutrition nonprofit Nourish Science and a former senior policymaker on food issues at the Food and Drug Administration and United States Department of Agriculture, said that a change to saturated fat recommendations would be a boon for the meat and dairy industries but that the food industry at large would likely prefer maintaining the status quo