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Excessive VEGF accelerates the degradation of tight junction proteins (ZO-1, claudin-5, occludin), increases the abundance of caveolae in the membranes of RECs, and directly disrupts the BRB, subsequently inducing retinal edema

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Potential Benefits: Significant Weight Loss: When combined with GLP-1 therapy, Cagrilintide has led to greater reductions in body weight than GLP-1s alone in clinical trials

Median OS of RT group and non-RT group in total patients were 10.7 vs 11.7 months (p=0.597), however those of two groups in high risk population were 11 vs 5 months (p 0.05)