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doi: 10.1016/j.prostaglandins.2009.04.001 63

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The GLP1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescenceaccelerated mouse model of Alzheimer's disease

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in analogy with the use of ACE inhibitors for hypertension, and based on clinical studies they proposed the use of DPP-4 inhibitors for the therapy of T2DM (101)

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Short-chain fatty acids (SFCAs) like acetate, butyrate and propionate, derived from host microbial fermentation of non-digestible carbohydrates, transduce signals through GPCR to promote anti-inflammatory cytokines (IL-10, IL-18) and Treg responses [198, 199] These SCFAs also suppress pro-inflammatory histone deacetylase (HDAC), NF-B and nitric oxide production, thus diminishing oxidative stress-induced epithelial cell apoptosis, and exerting a protective effect on colonic and cardiac health [199]

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