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Available evidence is primarily observational or from cell culturenot conclusive for clinical outcomes

The agency has not evaluated whether the unapproved products subject to the warning letters announced today are effective for their intended use, what the proper dosage might be, how they could interact with FDA-approved drugs or other substances, or whether they have dangerous side effects or other safety concerns

doi:10.1016/S0753-3322(03)00043-X Ubiyvovk VM, Ananin VM, Malyshev AY, Kang HA, Sibirny AA (2011) Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorpha DL-1

The duration of its effects can vary, typically lasting for several hours