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Conversely, diminished expression activity of the TEAD-YAP complex in OSCC cells contributes to a coordinated suppression of cyclins and cyclin-dependent kinases (CDKs), coupled with enhanced expression of CDK inhibitors
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Both approaches involve the attempt to remove malignant cells and spare normal tissues, though this remains difficult due to the heterogeneity of tumour s, intrinsic drug resistance and the ability of normal tissues to be affected adversely by anticancer treatments
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